Sulphonamides and Sulphones

The safety of antimalarial drugs in pregnancy.

Alternative drugs to chloroquine are required to prevent the deleterious effects of malaria in pregnancy. Fear of potential toxicity has limited antimalarial drug use in pregnancy. Animal toxicity studies have documented teratogenicity when antimalarials are administered at high dosages. Excepting the tetracyclines, there is no evidence to suggest that, at standard dosages, any of the antimalar...

ELISA inhibition technique for the demonstration of sulphones in body fluids. I. Sulphones specific antibody-enzyme conjugate.

Two enzyme-linked immunosorbent assays ( ELISA) for sulphones in body fluids were adapted to measure sulphones in blood dried on filter paper. The more sensitive modification , based on competition between dapsone (DDS) and enzyme-dapsone conjugate , detects sulphone in blood extracts up till 6 days following 1 00 mg DDS intake . Application to monitor patient compliance is demonstrated, using ...

The Present Status of Sulphones in the Treatment of Leprosy

Synthesis of Sulphones from Sulphonyl Fluorides and Organometallic Compounds

Introduction Recently, /3-disulphones wrere synthesised in high yields from sulphonyl fluorides by interaction with alkylmagnesium bromides [1]. It is assumed that this reaction proceeds through the formation of a monosulphone which undergoes a-metallation followed by further reaction with the sulphonyl fluoride to produce /?-disulphone. Since aromatic sulphones cannot be metallated at the a-po...

The Present Status of Sulphones in the Treatment of Leprosy

[This corrects the article on p. 348 in vol. 85.].